differential immunohistochemical expression pattern of galectin-3 in normal and osteoarthritic human articular cartilage
نویسندگان
چکیده
background: previous studies have shown that galectin-3, a member of lectin family, is expressed in developing cartilage in mouse embryo and also in growth plate of long bones. objective: in the present work, the expression pattern of galectin-3 in normal and various grades of osteoarthritic (oa) human articular cartilage has been studied. methods: using immunohistochemistry and standard western blotting, the in vivo and in vitro expression pattern of galectin-3 in normal and oa human articular cartilage were assessed. results: immunohistochemical studies showed a similar pattern of galectin-3 expression in normal and mild oa but severe oa showed different strong expression in all zones of human articular cartilage. conclusion: increased expression pattern of galectin-3 in advanced stages of oa may occur as a result of the imbalance of chondrocyte homeostasis that occurs in oa cartilage and provides a condition to modify normal chondrocyte to an oa chondroctye.
منابع مشابه
Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage
Background: Previous studies have shown that Galectin-3, a member of lectin family, is expressed in developing cartilage in mouse embryo and also in growth plate of long bones. Objective: In the present work, the expression pattern of Galectin-3 in normal and various grades of osteoarthritic (OA) human articular cartilage has been studied. Methods: Using immunohistochemistry and standard we...
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عنوان ژورنال:
iranian journal of immunologyجلد ۲، شماره ۲، صفحات ۷۸-۸۶
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